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KMID : 0043320150380111926
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Archives of Pharmacal Research
2015 Volume.38 No. 11 p.1926 ~ p.1931
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Chemical components from the leaves of Ardisia insularis and their cytotoxic activity
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Van Nguyen Thi Hong
Vien Trinh Anh
Kiem Phan Van
Minh Chau Van
Nhiem Nguyen Xuan
Long Pham Quoc
Anh Luu Tuan
Kim Nan-young
Park Seon-Ju
Kim Seung-Hyun
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Abstract
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One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3′-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.
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KEYWORD
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Ardisia insularis, Myrsinaceae, Ardinsuloside, Cytotoxic activity
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